Table 1 Summary of the role of fibroblast growth factors (FGFs) which influence on regeneration/neogenesis and growth/maintenance of hair follicle (HF).
| Subfamily | Role on HF | Detailed function | Animals | Location | Ref. | |
|---|---|---|---|---|---|---|
|
Regeneration Neogenesis |
Growth Maintenance | |||||
| FGF1s (1, 2) | ||||||
| FGF1 | + | + | Relates with HF differentiation, prevents radiation induced apoptosis of HFs | Ovine, mouse | KC | [15, 16] |
| FGF2 | + | + | Proliferates HF cells, induce HFs, lengthens anagen | Ovine, mouse | KC, DP | [15, 17,18,19] |
| FGF4s (4, 6, 5) | ||||||
| FGF5 | - | Induces catagen, inhibits hair growth by blocking DPC activation | Mouse, rat, cetasean, human | [20,21,22,23] | ||
| FGF7s (3, 7, 10, 22) | ||||||
| FGF7 | - | + | Protects HF from damage, lengthens anagen, blocks hair follicle induction, related HF texture, proliferates HGs, regulates HF structure | Human, mouse | DP, ORS | [6, 19, 24,25,26,27,28] |
| FGF10 | + | Regulates HF structure, required for HF formation/morphogenesis | Mouse | DP | [26, 29, 30] | |
| FGF9s (9, 16, 20) | ||||||
| FGF9 | + | Induces HF neogenesis after wounding | Mouse | γδT cells | [5, 31] | |
| FGF20 | + | Governs dermal condensation feather placode induction | Mouse, chicken | Hair placode | [32, 33] | |
| FGF8s (8, 17, 18) | ||||||
| FGF18 | − | Induces telogen, stem cell quiescence | Mouse | KC | [34,35,36] | |
| FGF19s (19, 21, 23) | ||||||
| FGF11s (11, 12, 13, 14) | ||||||
| FGF13 | + | Regulates function of bulge reduced in hypertrichosis | Mouse | Bulge region | [37] | |