| Autoinflammatory diseases: | |
| Cryopyrin-associated periodic syndrome (CAPS) [87, 88] | |
| Familial Mediterranean fever (FMF) [95] | |
| Pyogenic arthritis, pyoderma gangrenosum and acne syndrome (PAPA) [96] | |
| NLRP12 autoinflammatory syndrome [97] | |
| Tumor necrosis factor receptor-1-associated syndrome (TRAPS) [100] | |
| Hyperimmunoglobulinemia D and periodic fever syndrome (HIDS)/mevalonate kinase deficiency (MKD) [180] | |
| Deficiency of the interleukin-1-receptor antagonist (DIRA) [183] | |
| Autoimmune diseases: | |
| Psoriatic arthritis [191] | |
| Ankylosing spondylitis [192] | |
| Rheumatoid arthritis (RA) [196] | |
| Metabolic syndrome: | |
| Gout [203] | |
| Atherosclerosis [204] | |
| Type 2 diabetes mellitus (T2D) [204] | |
| Amyloidosis [207] | |
| Neurodegenerative disease: | |
| Alzheimer’s disease (AD) [111] | |
| Infections and inflammatory responses: | |
| Septic shock syndrome [199] | |
| Acute respiratory distress syndrome (ARDS) [199] | |
| Disseminated intravascular coagulation (DIC) [199] | |
| Hemophagocytic lymphohistiocytosis (HLH) [200] | |
| Macrophage-activating syndrome (MAS) [200] | |
| Ischemic diseases: | |
| Myocardial infarction (MI) [209] | |
| Stroke [209] | |
| Malignant rumor: | |
| Breast cancer [129] |